Lipopeptides: from self-assembly to bioactivity

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Lipopeptides: from self-assembly to bioactivity.

This Feature Article discusses several classes of lipopeptide with important biomedical applications as antimicrobial and antifungal agents, in immune therapies and in personal care applications among others. Two main classes of lipopeptide are considered: (i) bacterially-expressed lipopeptides with a cyclic peptide headgroup and (ii) linear lipopeptides (with one or more lipid chains) based on...

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This review describes the properties and activities of lipopeptides and peptide hormones and how the lipidation of peptide hormones could potentially produce therapeutic agents combating some of the most prevalent diseases and conditions. The self-assembly of these types of molecules is outlined, and how this can impact on bioactivity. Peptide hormones specific to the uptake of food and produce...

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Self-assembly of three bacterially-derived bioactive lipopeptides.

The self-assembly in aqueous solution of three lipopeptides obtained from Bacillus subtilis has been investigated. The lipopeptides surfactin, plipastatin and mycosubtilin contain distinct cyclic peptide headgroups as well as differences in alkyl chain length, branching and chain length distribution. Cryogenic transmission electron microscopy and X-ray scattering reveal that surfactin and plipa...

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Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly.

A series of heptapeptides comprising the core sequence Aβ(16-20), KLVFF, of the amyloid β peptide coupled with paired N-terminal γ-amino acids are investigated in terms of cytotoxicity reduction and binding to the full Aβ peptide, both pointing to inhibition of fibrillisation for selected compounds. This is related to the self-assembly capacity of the heptapeptides.

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Self-assembly is a fundamental mechanism by which structures form in materials. Over the past decades, a primary focus has been to relate materials’ behaviors to the spatial arrangement of their fundamental building blocks. These building blocks may comprise atoms, molecules, macromolecules and colloidal particles. It is well known that the same chemical substance can have vastly different prop...

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ژورنال

عنوان ژورنال: Chemical Communications

سال: 2015

ISSN: 1359-7345,1364-548X

DOI: 10.1039/c5cc01535a